Leonard P Rybak Selected Research

Drug Therapy (Chemotherapy)

9/2023	Effects of natural products on cisplatin ototoxicity and chemotherapeutic efficacy.
1/2023	Targeting CXCL1 chemokine signaling for treating cisplatin ototoxicity.
1/2018	The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss.
1/2017	Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.
1/2017	Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity.
4/2016	Adenosine A1 Receptor Protects Against Cisplatin Ototoxicity by Suppressing the NOX3/STAT1 Inflammatory Pathway in the Cochlea.
5/2011	The design and screening of drugs to prevent acquired sensorineural hearing loss.
9/2007	Ginkgo biloba extract (EGb 761) protects against cisplatin-induced ototoxicity in rats.
9/2004	Time response of carboplatin-induced nephrotoxicity in rats.
8/2002	Dose response of carboplatin-induced nephrotoxicity in rats.

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Leonard P Rybak Research Topics

Disease

36	Ototoxicity 09/2023 - 06/2002
26	Hearing Loss (Hearing Impairment) 09/2023 - 06/2002
19	Neoplasms (Cancer) 09/2023 - 08/2002
9	Inflammation (Inflammations) 01/2023 - 01/2006
3	Necrosis 01/2023 - 05/2002
3	Prostatic Neoplasms (Prostate Cancer) 01/2017 - 01/2012
3	Blister (Bulla) 05/2004 - 03/2003
2	Sensorineural Hearing Loss 09/2023 - 05/2011
2	Noise-Induced Hearing Loss (Acoustic Trauma) 11/2021 - 01/2019
2	Deafness (Deaf Mutism) 05/2019 - 06/2002
2	Wounds and Injuries (Trauma) 01/2019 - 05/2011
2	Neoplasm Metastasis (Metastasis) 12/2013 - 01/2012
2	Infections 05/2011 - 10/2005
1	Testicular Neoplasms (Testicular Cancer) 01/2023
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2021
1	Hidden Hearing Loss 01/2019
1	Cystic Fibrosis (Mucoviscidosis) 01/2016

Drug/Important Bio-Agent (IBA)

33	Cisplatin (Platino)FDA LinkGeneric 09/2023 - 05/2002
13	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 12/2003
10	AntioxidantsIBA 11/2021 - 04/2003
8	AminoglycosidesIBA 01/2021 - 10/2003
6	Small Interfering RNA (siRNA)IBA 01/2023 - 12/2008
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 10/2003
5	Protective AgentsIBA 01/2021 - 01/2005
5	Proteins (Proteins, Gene)FDA Link 05/2019 - 12/2008
4	Antineoplastic Agents (Antineoplastics)IBA 05/2019 - 03/2003
4	N-(1-methyl-2-phenylethyl)adenosine (S-PIA)IBA 01/2019 - 05/2004
4	Methionine (L-Methionine)FDA Link 01/2019 - 06/2002
4	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2016 - 09/2010
4	PlatinumIBA 10/2005 - 08/2002
4	Carboplatin (JM8)FDA LinkGeneric 06/2005 - 08/2002
3	Adenosine (Adenocard)FDA LinkGeneric 01/2019 - 02/2004
2	CaspasesIBA 01/2023 - 01/2021
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 05/2019 - 01/2017
2	Adenosine A1 ReceptorIBA 01/2017 - 04/2016
2	ResveratrolIBA 01/2017 - 01/2012
2	CytokinesIBA 01/2017 - 01/2006
2	PhenylisopropyladenosineIBA 04/2016 - 01/2010
2	SERPIN-B5 (maspin)IBA 12/2013 - 01/2012
2	Androgen Receptors (Androgen Receptor)IBA 12/2013 - 01/2012
2	MicroRNAs (MicroRNA)IBA 12/2013 - 01/2012
2	RNA (Ribonucleic Acid)IBA 01/2012 - 09/2010
2	Therapeutic UsesIBA 11/2009 - 10/2007
2	EnzymesIBA 10/2007 - 04/2003
2	Phosphates (Orthophosphate)IBA 01/2004 - 03/2003
1	Glutamic Acid (Glutamate)FDA Link 01/2023
1	SB 225002IBA 01/2023
1	CXC ChemokinesIBA 01/2023
1	Interleukin-8B ReceptorsIBA 01/2023
1	Chemokine CXCL1IBA 01/2023
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 11/2021
1	Capreomycin (Capastat)FDA Link 01/2021
1	Vancomycin FDA LinkGeneric 01/2021
1	MacrolidesIBA 01/2021
1	Peptides (Polypeptides)IBA 01/2021
1	Erythromycin (Erycette)FDA LinkGeneric 01/2021
1	Gentamicins (Gentamicin)FDA LinkGeneric 01/2021
1	Clarithromycin (Biaxin)FDA LinkGeneric 01/2021
1	Azithromycin (Zithromax)FDA LinkGeneric 01/2021
1	GTP-Binding Proteins (G-Protein)IBA 05/2019
1	Cyclin-Dependent Kinase 2IBA 01/2019
1	kenpaulloneIBA 01/2019
1	pifithrinIBA 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Etanercept (Enbrel)FDA Link 01/2019
1	MelatoninIBA 01/2019
1	SteroidsIBA 01/2019
1	Caffeine (No Doz)FDA LinkGeneric 01/2019
1	AMP-Activated Protein Kinase KinasesIBA 01/2019
1	iodopravadoline (AM 630)IBA 01/2018
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2018
1	Adenosine Triphosphatases (ATPase)IBA 01/2018
1	EndocannabinoidsIBA 01/2018
1	Long Noncoding RNAIBA 01/2017
1	CannabinoidsIBA 01/2017
1	Interleukin-6 (Interleukin 6)IBA 01/2017
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2017
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 01/2017
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2017
1	Apoptosis Regulatory ProteinsIBA 01/2017
1	Transcription Factors (Transcription Factor)IBA 10/2016
1	STAT1 Transcription FactorIBA 10/2016
1	Tobramycin (Nebcin)FDA LinkGeneric 01/2016
1	Investigational DrugsIBA 02/2015
1	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 12/2013
1	OligonucleotidesIBA 01/2012
1	Capsaicin (Zostrix)FDA Link 03/2011
1	Protein Isoforms (Isoforms)IBA 09/2010
1	Messenger RNA (mRNA)IBA 01/2010
1	Ginkgo biloba extract (Rokan)IBA 09/2007
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2006
1	LipopolysaccharidesIBA 01/2006

Therapy/Procedure

10	Drug Therapy (Chemotherapy) 09/2023 - 08/2002
3	Therapeutics 01/2019 - 05/2011
3	Injections 04/2016 - 03/2011
2	Oral Administration 01/2019 - 01/2012
1	Cochlear Implantation 11/2021
1	Intratympanic Injection 09/2010
1	Chemoprevention 04/2007